Prof. Jan J Grote
President of IFOS; and Clinical Professor ENT
Department of ENT, University Hospital, Leiden, The Netherlands
PROFESSIONAL EDUCATION AND POSITIONS HELD:
Medicine : University of Groningen 1960-1968
Army service : Final rank colonel
First Service : 1968-1970
Residence in ENT : University Hospital Nijmegen 1970-1974
Fellowship in ENT : Dundee, Royal Infirmary, Scotland, 1972
PhD thesis : Autonomic innervation of the nasal mucosa (Nijmegen)
Private practice : Roermond 1974-1980
Cooperation with the Fondren Foundation
Methodist Hospital, Houston, USA
1975-1977
Research Fellow ENT-Dept Nijmegen : 1974-1980
Clinical Prof. ENT, University Leiden : 1980 - present
Chairman of the ENT Department :1991 - 2004
General Secretary : 2001 - present
International Federation of Oto-Laryngological Societies (IFOS)
MAIN AREAS OF RESEARCH:
1. Surgical hearing rehabilitation
Interest introduction of hydroxyapatite in
Otology. Development of an
Electro-magnetic implantable hearing
Device
Cochlear models for cochlear
Stimulation with cochlear implant
Electrodes
2. Pathogenesis of otitis media
- Introduction of in vitro studies of the middle ear tissues
- Study of the effect of endo- and exotoxines on the pathogenesis of
Chronic middle ear disease
Published two books and chapters in different books.
More than 170 scientific papers in international journals concerning the
different subjects of interest.
TEACHING EXPERIENCE:
- Courses in general medicine for medical students
- Postgraduate course in Otology and Paranasal Sinus Surgery
- Dean of the Postgraduate Education of the Medical Faculty of Leiden University
- Research programs of residents in MD and Ph.D.
- Boards Committees and Advisorships
MEMBERSHIPS:
Dutch ENT Society
American Academy of Otorhinolaryngology Head and Neck Surgery, American Research Society AROS
Collegium Otorhinolaryngologicum Amaecitiae Sacrum (CORLAS)
Politzer Society
Founder Member of the European Academy of Otology and Neuro-otology and Skull Base Surgery
Honorary member of the Swedish Otosurgery Society
Honorary member of the Polish Otorhinolaryngological Society
LOCAL COMMITTEES:
Chairman of the Boerhaave Committee for postgraduate medical education (until 1999)
Member of the management team of Division III of the University of Leiden
Member of the Advisory Board of the University Hospital
President of the Board of Alumni Organization LUF of the University of Leiden (until 2000).
NATIONAL
Chairman of the training Committee of the Dutch ENT Society
Chairman of the inspection Committee of the Dutch ENT Society
Member of the Dutch Concilium of Otorhinolaryngology (chairman)
Member of the Dutch Concilium Audiologicum
Founding Member of the Dutch working group for Otitis Media
Editor of the Dutch Journal of Medicine (NTVG)
Founder and vice-chairman of the National Dutch Hearing Foundation
Chairman of NOAH (Nationaal Overleg Audiologische Hulpmiddelen)
Member Gezondheidscommissie - Cochlear Implant Children
Member RGO (Raad voor Advies Gezondheidsonderzoek) Hearing Research
INTERNATIONAL
Editor of ORL Digest
Editor of Clinical Otolaryngology
Editor of Acta Otolaryngologica
Regional Secretary for Europe for IFOS (International Federation of Otorhinology (until December 2001)
General Secretary for the World for IFOS (from December 2001)
Founding member of the European Academy of Otology and Neuro-otology.
SELECTION OF PAST FUNCTIONS:
- Board member of the Dutch ENT Society
- Vice chairman of the clinical staff of the University Hospital Leiden
- Vice Dean of the Medical Faculty University Leiden
- Founder of CAM implants Company
RESEARCH SYNOPSIS
1. Autonomic innervation of the nasal mucous membrane
In my PhD study I was interested in the autonomic innervation of the nasal mucous membrane, in relation with vidian neurectomy which was performed in those days. It turned out that the autonomic innervation of the nasal mucous membrane was unknown and, in an experiment, selective denervation was performed and with immunohistological methods and physiological methods the effect of the different selective denervations could be followed. In this way the pattern of the autonomic innervation of the nasal mucous membrane was demonstrated and also the reinnervation after postoperative control. This indicated that the videan neurectomy was not the therapy of choice for autonomic innervation problems of the nasal mucous membrane, because of the recurrence after the operation. This is proven in the clinic.
2. Middle ear reconstruction
In 1974 – 1976 a series of homologous total implants in middle ear surgery was performed. The experience with the closed techniques and problems with the homologous implants was the reason to start with the concept of a total artificial middle ear.
Therefore, a biomaterial study was started with the experience in celbiology and surgical experience with the homologous implants. From different biomaterials hydroxyapatite, as a calciumphosphate, was developed and introduced in Otology in 1980. For the total artificial middle ear also a tympanic membrane/malleus prosthesis was necessary, and therefore, research was done in the soft tissue replacement. A copolymer was developed as a first bioactive resorbable polymer for reconstructive surgery. Hydroxyapatite is now accepted in Otology worldwide as a material of choice. The artificial tympanic membrane was not introduced in the clinic, because of the long-term results.
3. Electro-magnetic stimulation
Because of the problems of the conventional hearing aid, I am interested in the development of an implantable hearing aid to avoid the problems of microphone and telephone. The telephone part is replaced by an implantable magnet on the ossicular chain. The electro-magnetic device is implanted in 5 patients and an improved device is developed at the moment in cooperation with Philips.
This technique is studied for the combination of electric and auditive stimulation in cochlear implants.
4. Cochlear stimulation
Research is done with new models for cochlear stimulation in the bone of the cochlea, in order to keep the membraneous labyrinth intact. New stimulus patterns in this way are developed. In the clinic based on modelling approach a new line of cochlear stimulation is studied.
5. Pathogenesis of otitis media
With experiments and in vitro studies, the otitis media is studied with a special interest for the pathogenesis of chronic otitis media. A model is developed and the exogenous and endogenous stimuli involved in the chronic otitis media are tested. The basis of this work is done by single stimuli via in vitro studies in which middle ear mucosa, tympanic membrane and cholesteatoma matrix is cultured. So far, it could be demonstrated that O2/C02 contents has only a little value in the development of changes in the middle ear mucosa as seen in otitis media. It is demonstrated that the endotoxins and exotoxines are an important stimulus and influence on middle ear mucosa could be demonstrated. In vitro it was also possible to demonstrate the neutralising effect of developed peptides against bacterial toxins.
With the peptides it is possible in experiments to change chronic diseased mucosa in normal mucosa. Clinical studies are in preparation.
Seminars & Talks
- A global perspective on resourcing childhood deafness
Friday May 13th 2005 12:00pm — 12:30pm
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